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Understanding and controlling circuit function through plasticity

In the Bharioke Lab, we study cortical circuits from their initial formation during development to their function in the adult, identifying the rules underlying circuit plasticity, and using these rules to control circuit function.

Our Research

The neocortex is the seat of higher order cognitive function in mammals. Yet, the rules by which neurons within the neocortex form connected circuits, and the way in which those connected circuits then generate the cognitive functions that define who we are remain poorly understood.

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In the Bharioke Lab, we explore these questions throughout the lifespan - from the embryonic formation of cortical circuits, through to their function in cognitive state changes in the adult. 

Publications

Para-uterine Embryonic Imaging of Developing Cortical Circuits

Given the importance of the neuronal circuits in generating the cognitive functions of the cerebral cortex, it's crucial to understand how these circuits first form during cortical development? Our recent publication utilizes a novel method of para-uterine embryonic imaging to answer this question.

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We recorded from cortical neurons through embryonic development, from their entry into the cortical plate onwards. This developmental window had previously never been accessible, in vivo. We found that neurons, transcriptomically labeled as embryonic layer 5 pyramidal neurons, form transient circuits with correlated activity, even as early as embryonic day 14.5. 

Interested in the questions we are working on? The Bharioke Lab is now taking on researchers at all levels.
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Dept. of Neuroscience, Medical University of South Carolina

bharioke@musc.edu

© 2024 by Arjun Bharioke

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